PRKAB2

Function

Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

Post-translational modifications

Phosphorylated when associated with the catalytic subunit (PRKAA1 or PRKAA2). Phosphorylated by ULK1 and ULK2; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1, ULK2 and AMPK.

Sequence Similarities

Belongs to the 5'-AMP-activated protein kinase beta subunit family.

Alternative names

5'-AMP-activated protein kinase subunit beta-2, AMPK subunit beta-2, PRKAB2

Database links

swissprot:O43741 omim:602741 omim:604976 omim:602739 entrezGene:51422 omim:602743 swissprot:Q13131 swissprot:Q9UGI9 swissprot:Q9UGJ0 entrezGene:5565 entrezGene:5562 entrezGene:53632