PRKAR2A phospho S99
Function
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
Post-translational modifications
Phosphorylated by the activated catalytic chain.
Sequence Similarities
Belongs to the cAMP-dependent kinase regulatory chain family.
Tissue Specificity
Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.
Cellular localization
- Cytoplasm
- Cell membrane
- Colocalizes with PJA2 in the cytoplasm and the cell membrane.
Alternative names
PKR2, PRKAR2, PRKAR2A, cAMP-dependent protein kinase type II-alpha regulatory subunit