PRLR
Domain
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.
Function
This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.
Involvement in disease
Multiple fibroadenomas of the breast
MFAB
A benign breast disease marked by lobuloalveolar growth with abnormally high proliferation of the epithelium, and characterized by the presence of more than 3 fibroadenomas in one breast. Fibroadenomas are adenomas containing fibrous tissue.
None
The disease is caused by variants affecting the gene represented in this entry.
Hyperprolactinemia
HPRL
A disorder characterized by increased levels of prolactin in the blood not associated with gestation or the puerperium. HPRL may result in infertility, hypogonadism, and galactorrhea.
None
The disease is caused by variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the type I cytokine receptor family. Type 1 subfamily.
Tissue Specificity
Expressed in breast, placenta, kidney, liver and pancreas.
Cellular localization
- Membrane
- Single-pass type I membrane protein
- Isoform 7
- Secreted
Alternative names
Prolactin receptor, PRL-R, PRLR