Prlr
Domain
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.
Function
This is a receptor for the anterior pituitary hormone prolactin.
Sequence Similarities
Belongs to the type I cytokine receptor family. Type 1 subfamily.
Cellular localization
- Membrane
- Single-pass type I membrane protein
Alternative names
Prolactin receptor, PRL-R, Lactogen receptor, Prlr