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Prolactin Receptor/PRL-R

Domain

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

The box 1 motif is required for JAK interaction and/or activation.

Function

This is a receptor for the anterior pituitary hormone prolactin.

Sequence similarities

Belongs to the type I cytokine receptor family. Type 1 subfamily.

Cellular localization

  • Membrane
  • Single-pass type I membrane protein

Alternative names

Prolactin receptor, PRL-R, Lactogen receptor, Prlr

Target type

Proteins

Primary research area

Developmental Biology

Molecular weight

68599Da