PRM2
Function
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.
Post-translational modifications
Proteolytic processing into mature chains is required for histone eviction during spermatogenesis. Transition proteins (TNP1 and TNP2) are required for processing.
Sequence Similarities
Belongs to the protamine P2 family.
Tissue Specificity
Testis.
Cellular localization
- Nucleus
- Chromosome
Alternative names
Protamine-2, Sperm histone P2, Sperm protamine P2, PRM2