PRMT2
Function
Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation.
Sequence Similarities
Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
Tissue Specificity
Widely expressed. Highly expressed in androgen target organs such as heart, prostate, skeletal muscle, ovary and spinal cord.
Cellular localization
- Isoform 1
- Cytoplasm
- Nucleus
- Translocates from the cytoplasm to the nucleus, after hormone exposure. Excluded from nucleolus.
- Isoform PRMT2Alpha
- Nucleus
- Excluded from nucleolus.
- Isoform PRMT2Beta
- Cytoplasm
- Nucleus
- Nucleus
- Nucleolus
- Isoform PRMT2Gamma
- Nucleus
- Excluded from nucleolus.
- Isoform PRMT2L2
- Cytoplasm
- Nucleus
- Predominantly cytoplasmic.
Alternative names
HMT1, HRMT1L1, PRMT2, Protein arginine N-methyltransferase 2, Histone-arginine N-methyltransferase PRMT2