PRND
Domain
A short helical region is required and sufficient for Cu(2+) binding.
Function
Required for normal acrosome reaction and for normal male fertility (By similarity). Can bind Cu(2+) (PubMed:15218028, PubMed:20411530).
Post-translational modifications
N-glycosylated. N-glycosylated at two distinct sites.
O-glycosylated.
Sequence Similarities
Belongs to the prion family.
Tissue Specificity
Expressed in testis, in Sertoli cells, ejaculated spermatozoa and in seminal fluid (at protein level).
Cellular localization
- Cell membrane
- Lipid-anchor
- GPI-anchor
Alternative names
DPL, UNQ1830/PRO3443, PRND, Prion-like protein doppel, PrPLP, Prion protein 2