Proc
Function
Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function.
Post-translational modifications
The vitamin K-dependent, enzymatic carboxylation of some Glu residues allows the modified protein to bind calcium.
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
Sequence Similarities
Belongs to the peptidase S1 family.
Tissue Specificity
Plasma; synthesized in the liver.
Cellular localization
- Secreted
- Golgi apparatus
- Endoplasmic reticulum
Alternative names
Vitamin K-dependent protein C, Anticoagulant protein C, Autoprothrombin IIA, Blood coagulation factor XIV, Proc