PRODH2
Function
Dehydrogenase that converts trans-4-L-hydroxyproline to delta-1-pyrroline-3-hydroxy-5-carboxylate (Hyp) using ubiquinone-10 as the terminal electron acceptor. Can also use proline as a substrate but with a very much lower efficiency. Does not react with other diastereomers of Hyp: trans-4-D-hydroxyproline and cis-4-L-hydroxyproline. Ubiquininone analogs such as menadione, duroquinone and ubiquinone-1 react more efficiently than oxygen as the terminal electron acceptor during catalysis.
Sequence Similarities
Belongs to the proline oxidase family.
Alternative names
HSPOX1, HYPDH, PRODH2, Hydroxyproline dehydrogenase, Kidney and liver proline oxidase 1, Probable proline dehydrogenase 2, Probable proline oxidase 2, HsPOX1