pros
Developmental stage
In embryos, expressed mainly in neuronal precursors but detected also in cells lining the gut and Garland cells (at protein level) (PubMed:1540176, PubMed:1720353, PubMed:20152183, PubMed:27510969). Expressed during embryogenesis in different cells of the central and peripheral nervous system including neuroblasts and ganglion mother cells (GMC) (PubMed:1720353, PubMed:1842358).
Domain
The Prospero-type homeodomain and the adjacent Prospero domain act as a single structural unit, the Homeo-Prospero domain.
Function
Homeodomain protein that controls neuronal identity (PubMed:1842358). As a transcriptional factor, regulates the expression of ftz, eve and en in a subset of neuroblast progeny and modulates the transcriptional activity of other homeodomain proteins such as Dfd (PubMed:12429095, PubMed:15837198, PubMed:9380747). Required for proper neuronal differentiation, axonal outgrowth and pathfinding of most or all neurons and their precursors in central and peripheral nervous systems (PubMed:11051550, PubMed:1540176, PubMed:16564014, PubMed:1720353, PubMed:18342578, PubMed:1842358, PubMed:20152183, PubMed:23056424, PubMed:27510969). Regulates asymmetric stem cell self-renewal together with brat (PubMed:16564014).
Sequence Similarities
Belongs to the Prospero homeodomain family.
Cellular localization
- Nucleus
- Cytoplasm
- Cell cortex
- Cytoplasm
- Dispersed in the cytoplasm of mitotic ganglion mother cells (GMCs) and neuroblast-like cell type.
Alternative names
CG17228, pros, Homeobox protein prospero