Prostaglandin E2 receptor EP2 subtype

Function

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Tissue Specificity

Placenta and lung.

Cellular localization

• Cell membrane
• Multi-pass membrane protein

Alternative names

Prostaglandin E2 receptor EP2 subtype, PGE receptor EP2 subtype, PGE2 receptor EP2 subtype, Prostanoid EP2 receptor, PTGER2

Database links

swissprot:P43116 swissprot:O00325 entrezGene:5733 entrezGene:5732 omim:176806 omim:176804