Prostasin
Function
Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G).
Sequence Similarities
Belongs to the peptidase S1 family.
Tissue Specificity
Found in prostate, liver, salivary gland, kidney, lung, pancreas, colon, bronchus and renal proximal tubular cells. In the prostate gland it may be synthesized in epithelial cells, secreted into the ducts, and excreted into the seminal fluid.
Cellular localization
- Prostasin
- Cell membrane
- Single-pass membrane protein
- Prostasin light chain
- Secreted
- Extracellular space
- Found in the seminal fluid. Secreted after cleavage of its C-terminus.
- Prostasin heavy chain
- Secreted
- Extracellular space
- Found in the seminal fluid. Secreted after cleavage of its C-terminus.
Alternative names
Prostasin, Channel-activating protease 1, Serine protease 8, CAP1, PRSS8