Protein kinase C and casein kinase substrate in neurons protein 3
Domain
The F-BAR domain forms a coiled coil and mediates membrane-binding and membrane tubulation.
Function
Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity).
Post-translational modifications
Phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC).
Sequence Similarities
Belongs to the PACSIN family.
Tissue Specificity
Widely expressed, with highest levels in heart and skeletal muscle, intermediate levels in placenta, liver and pancreas, and very low levels in brain, lung and kidney.
Cellular localization
- Cytoplasm
- Cell membrane
- Peripheral membrane protein
- Cytoplasmic side
- Detected at the inner aspect of the plasma membrane in myotubes.
Alternative names
Protein kinase C and casein kinase substrate in neurons protein 3, SH3 domain-containing protein 6511, PACSIN3