Protein kinase C and casein kinase substrate in neurons protein 3

The F-BAR domain forms a coiled coil and mediates membrane-binding and membrane tubulation.

Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity).

Phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC).

Belongs to the PACSIN family.

Widely expressed, with highest levels in heart and skeletal muscle, intermediate levels in placenta, liver and pancreas, and very low levels in brain, lung and kidney.

• Cytoplasm
• Cell membrane
• Peripheral membrane protein
• Cytoplasmic side
• Detected at the inner aspect of the plasma membrane in myotubes.

Protein kinase C and casein kinase substrate in neurons protein 3, SH3 domain-containing protein 6511, PACSIN3

• entrezGene:29763
• omim:606513
• swissprot:Q9UKS6

Proteins

Neuroscience

48487Da