Protein OS-9
Function
Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4.
Post-translational modifications
Intramolecular disulfide bonds.
Isoform 1 and isoform 2 are N-glycosylated.
Sequence Similarities
Belongs to the OS-9 family.
Tissue Specificity
Ubiquitously expressed. Found as well in all tumor cell lines analyzed, amplified in sarcomas. Highly expressed in osteosarcoma SJSA-1 and rhabdomyosarcoma Rh30 cell lines. Isoform 2 is the major isoform detected in all cell types examined.
Cellular localization
- Endoplasmic reticulum lumen
Alternative names
Protein OS-9, Amplified in osteosarcoma 9, OS9