Protein S100-A13
Function
Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine (By similarity).
Sequence Similarities
Belongs to the S-100 family.
Tissue Specificity
Expressed in heart and skeletal muscle.
Cellular localization
- Cytoplasm
- Secreted
- Secretion is mediated by exposure to stress and requires copper ions.
Alternative names
Protein S100-A13, S100 calcium-binding protein A13, S100A13