Protein SLFN14

Protein SLFN14

Shows no ribosome-associated and endoribonuclease activities.

C-terminally truncated SLFN14 endoribonuclease

Displays polysome-associated endoribonuclease activity towards mRNAs and rRNAs (PubMed:25996083). May play a role in RNA surveillance pathways by recognizing stalled ribosomes and triggering endonucleolytic cleavage of aberrant mRNAs (Probable). Cleaves different types of rRNAs and mRNAs in a magnesium- and manganese-dependent and ATP-independent manner (By similarity). Involved in correct maturation of megakaryocytes and especially important for proplatelet extension.

Bleeding disorder, platelet-type, 20

BDPLT20

A disorder characterized by increased bleeding tendency due to platelet dysfunction. Clinical features include epistaxis, hematomas, bleeding after tooth extraction, and menorrhagia. BDPLT20 is characterized by moderate thrombocytopenia and platelet secretion defects. Inheritance is autosomal dominant.

None

The disease is caused by variants affecting the gene represented in this entry.

Belongs to the Schlafen family. Subgroup III subfamily.

Expressed in megakaryocytes and platelets (at protein level) (PubMed:26280575). Weakly expressed in melanocytes and malignant melanoma cells (PubMed:20956525).

• Protein SLFN14
• Nucleus

Protein SLFN14, SLFN14

• entrezGene:342618
• swissprot:P0C7P3

Proteins

Immuno-oncology

103907Da