Protein sprouty homolog 2
Domain
The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles.
Function
Antagonist of fibroblast growth factor (FGF) pathways via inhibition of FGF-mediated phosphorylation of ERK1/2 (By similarity). Thereby acts as an antagonist of FGF-induced retinal lens fiber differentiation, may inhibit limb bud outgrowth and may negatively modulate respiratory organogenesis (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in retinal lens epithelial cells (By similarity). Inhibits CBL/C-CBL-mediated EGFR ubiquitination (PubMed:17974561).
Involvement in disease
IgA nephropathy 3
IGAN3
A form of IgA nephropathy, a common primary glomerulonephritis characterized by glomerular sclerosis, interstitial fibrosis, and mesangial glomerular deposits of immunoglobulin A and immunoglobulin G visible on renal biopsies. IgA nephropathy is associated with renal insufficiency that can progress to end-stage renal disease. Proteinuria and hematuria are characteristic clinical presentations.
None
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Post-translational modifications
Cleaved at Pro-144 by the prolyl endopeptidase FAP (seprase) activity (in vitro).
Sequence Similarities
Belongs to the sprouty family.
Cellular localization
- Cytoplasm
- Cytoskeleton
- Cell projection
- Ruffle membrane
- Associated with microtubules in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor).
Alternative names
Protein sprouty homolog 2, Spry-2, SPRY2