Protein sprouty homolog 3
Function
Inhibits neurite branching, arbor length and neurite complexity (By similarity). Inhibits EGF-mediated p42/44 ERK signaling (By similarity). Negatively regulates the MAPK cascade, resulting in a reduction of extracellular matrix protein accumulation (PubMed:30878395). May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis (PubMed:9458049).
Sequence Similarities
Belongs to the sprouty family.
Tissue Specificity
Widely expressed; particularly in the fetal tissues. Expressed in the brain with expression the highest in Purkinje cells in the cerebellum (at protein level) (PubMed:26089202). Expressed in the myocardium of the heart (PubMed:30878395).
Cellular localization
- Cytoplasm
Alternative names
Protein sprouty homolog 3, Spry-3, Sprouty RTK signaling antagonist 3, Sprouty3, SPRY3