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Protein tweety homolog 1

Function

Calcium-independent, swelling-dependent volume-regulated anion channel (VRAC-swell) which plays a pivotal role in the process of regulatory volume decrease (RVD) in the brain through the efflux of anions like chloride and organic osmolytes like glutamate.

Isoform 3

Ca(2+)-independent, swelling-activated chloride channel, possibly involved in regulation of cell volume.

Post-translational modifications

N-glycosylated. Contains high-mannose, hybrid and complex oligosaccharides.

Sequence similarities

Belongs to the tweety family.

Tissue specificity

Expressed in brain, eye, ovary and testis, and at lower levels in muscle, placenta, liver and lung.

Cellular localization

  • Cell membrane
  • Multi-pass membrane protein

Alternative names

Protein tweety homolog 1, hTTY1, Volume-regulated anion channel subunit TTYH1, TTYH1

Target type

Proteins

Primary research area

Neuroscience

Molecular weight

49051Da

We found 1 product in 1 category

Primary Antibodies

Target

Application

Reactive species

Search our catalogue for 'Protein tweety homolog 1' (1)

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