Protein Wnt-8b
Function
Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus.
Post-translational modifications
Palmitoleoylation is required for efficient binding to frizzled receptors (By similarity). Depalmitoleoylation leads to Wnt signaling pathway inhibition (By similarity).
Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of WNT8B.
Sequence Similarities
Belongs to the Wnt family.
Tissue Specificity
Expression is restricted to the brain, and more specifically to the forebrain.
Cellular localization
- Secreted
- Extracellular space
- Extracellular matrix
Alternative names
Protein Wnt-8b, WNT8B