Protransforming growth factor alpha
Function
TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.
Tissue Specificity
Isoform 1, isoform 3 and isoform 4 are expressed in keratinocytes and tumor-derived cell lines.
Cellular localization
- Transforming growth factor alpha
- Secreted
- Extracellular space
- Protransforming growth factor alpha
- Cell membrane
- Single-pass type I membrane protein
Alternative names
Protransforming growth factor alpha, TGFA