PROZ
Function
Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles. Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids.
Post-translational modifications
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
Sequence Similarities
Belongs to the peptidase S1 family.
Tissue Specificity
Plasma.
Cellular localization
- Secreted
Alternative names
Vitamin K-dependent protein Z, PROZ