PRPF40A
Domain
The WW domains are essential for localization to nuclear speckles.
Function
Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing.
Sequence Similarities
Belongs to the PRPF40 family.
Tissue Specificity
Expressed in the brain cortex (at protein level). Widely expressed.
Cellular localization
- Nucleus speckle
- Nucleus matrix
- Colocalizes with AKAP8L in the nuclear matrix.
Alternative names
FBP11, FLAF1, FNBP3, HIP10, HYPA, HSPC225, PRPF40A, Pre-mRNA-processing factor 40 homolog A, Fas ligand-associated factor 1, Formin-binding protein 11, Formin-binding protein 3, Huntingtin yeast partner A, Huntingtin-interacting protein 10, Huntingtin-interacting protein A, Renal carcinoma antigen NY-REN-6, HIP-10