Prph
Function
Class-III neuronal intermediate filament protein (PubMed:2624740, PubMed:3339087). My form an independent structural network without the involvement of other neurofilaments or may cooperate with the neuronal intermediate filament proteins NEFL, NEFH, NEFM and INA to form a filamentous network (By similarity). Assembly of the neuronal intermediate filaments may be regulated by RAB7A (By similarity). Plays a role in the development of unmyelinated sensory neurons (By similarity). May be involved in axon elongation and axon regeneration after injury (PubMed:2585054, PubMed:7530776). Inhibits neurite extension in type II spiral ganglion neurons in the cochlea (By similarity).
Post-translational modifications
Phosphorylated; phosphorylation increases after nerve injury in regenerating neurons.
Sequence Similarities
Belongs to the intermediate filament family.
Tissue Specificity
Expressed in hypoglossal motor neurons (at protein level) (PubMed:17569669, PubMed:2126481). Expressed in the small and large sensory neurons of the dorsal root ganglion (at protein level) (PubMed:2126481, PubMed:2585054, PubMed:9388258). Expressed in cutaneous and muscular sensory neurons (PubMed:19913522).
Cellular localization
- Cytoplasm
- Cytoskeleton
- Cell projection
- Axon
- Perikaryon
Alternative names
Prph1, Prph, Peripherin