PRPH

Class-III neuronal intermediate filament protein (PubMed:2624740, PubMed:3339087). My form an independent structural network without the involvement of other neurofilaments or may cooperate with the neuronal intermediate filament proteins NEFL, NEFH, NEFM and INA to form a filamentous network (By similarity). Assembly of the neuronal intermediate filaments may be regulated by RAB7A (By similarity). Plays a role in the development of unmyelinated sensory neurons (By similarity). May be involved in axon elongation and axon regeneration after injury (PubMed:2585054, PubMed:7530776). Inhibits neurite extension in type II spiral ganglion neurons in the cochlea (By similarity).

Phosphorylated; phosphorylation increases after nerve injury in regenerating neurons.

Belongs to the intermediate filament family.

Expressed in hypoglossal motor neurons (at protein level) (PubMed:17569669, PubMed:2126481). Expressed in the small and large sensory neurons of the dorsal root ganglion (at protein level) (PubMed:2126481, PubMed:2585054, PubMed:9388258). Expressed in cutaneous and muscular sensory neurons (PubMed:19913522).

• Cytoplasm
• Cytoskeleton
• Cell projection
• Axon
• Perikaryon

Prph1, Prph, Peripherin

• entrezGene:24688
• swissprot:P21807

Proteins

Neuroscience

53550Da