PRSS1

Function

Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates.

Involvement in disease

Pancreatitis, hereditary

PCTT

A disease characterized by pancreas inflammation, permanent destruction of the pancreatic parenchyma, maldigestion, and severe abdominal pain attacks.

None

Disease susceptibility is associated with variants affecting the gene represented in this entry.

Post-translational modifications

Occurs in a single-chain form and a two-chain form, produced by proteolytic cleavage after Arg-122.

Sulfation at Tyr-154 increases selectivity towards basic versus apolar residues at the P2' position of inhibitors that bind in a substrate-like fashion. Although the increase in selectivity is relatively small, it may facilitate digestion of a broader range of dietary proteins.

Sequence Similarities

Belongs to the peptidase S1 family.

Cellular localization

• Secreted
• Extracellular space

Alternative names

TRP1, TRY1, TRYP1, PRSS1, Serine protease 1, Anionic trypsin I, Anionic trypsin-I, Beta-trypsin, Cationic trypsinogen, Pretrypsinogen I, Trypsin I, Trypsin-1

Database links

swissprot:P07477 entrezGene:5646 entrezGene:5645 entrezGene:5644 swissprot:P35030 swissprot:P07478 omim:613578 omim:601564 omim:276000