PRSS2
Function
In the ileum, may be involved in defensin processing, including DEFA5.
Post-translational modifications
Sulfated on tyrosine.
Sulfation at Tyr-154 increases selectivity towards basic versus apolar residues at the P2' position of inhibitors that bind in a substrate-like fashion. Although the increase in selectivity is relatively small, it may facilitate digestion of a broader range of dietary proteins.
Sequence Similarities
Belongs to the peptidase S1 family.
Tissue Specificity
Expressed in Paneth cells, at the base of small intestinal crypts.
Cellular localization
- Secreted
- Extracellular space
Alternative names
TRY2, TRYP2, PRSS2, Trypsin-2, Anionic trypsinogen, Serine protease 2, Trypsin II