PRSS2

In the ileum, may be involved in defensin processing, including DEFA5.

Sulfated on tyrosine.

Sulfation at Tyr-154 increases selectivity towards basic versus apolar residues at the P2' position of inhibitors that bind in a substrate-like fashion. Although the increase in selectivity is relatively small, it may facilitate digestion of a broader range of dietary proteins.

Belongs to the peptidase S1 family.

Expressed in Paneth cells, at the base of small intestinal crypts.

• Secreted
• Extracellular space

TRY2, TRYP2, PRSS2, Trypsin-2, Anionic trypsinogen, Serine protease 2, Trypsin II

• entrezGene:5645
• omim:601564
• swissprot:P07478

Proteins

Oncology

26488Da