PRUNE2
Developmental stage
Induced during the G1 phase of the cell cycle.
Function
May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells.
Sequence Similarities
Belongs to the PPase class C family. Prune subfamily.
Tissue Specificity
A high level of expression seen in the nervous system (brain, cerebellum and spinal cord) as well as adrenal gland. Expressed at high levels in noneuroblastoma, rhabdomyosarcoma, melanoma and some osteosarcoma cell lines, whereas at only low levels in cancer cell lines of liver, breast, thyroid and colon. Expression is significantly higher in favorable tumors than aggressive ones.
Cellular localization
- Cytoplasm
Alternative names
BMCC1, BNIPXL, C9orf65, KIAA0367, PRUNE2, Protein prune homolog 2, BNIP2 motif-containing molecule at the C-terminal region 1