PSD4
Function
Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate.
Tissue Specificity
Widely expressed. Highest levels of expression are found in placenta, pancreas, spleen, thymus and peripheral blood.
Cellular localization
- Cell membrane
- Cell projection
- Ruffle membrane
- In interphase associated with the plasma membrane, in particular with membrane ruffling regions (PubMed:23603394). Accumulates in dynamic actin-rich membrane ruffles and microvilli-like structures (PubMed:12082148). Recruited to membranes via phosphatidylinositol phosphate-binding (Probable).
Alternative names
EFA6B, TIC, PSD4, PH and SEC7 domain-containing protein 4, Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B, Pleckstrin homology and SEC7 domain-containing protein 4, Telomeric of interleukin-1 cluster protein, Exchange factor for ARF6 B