PSMA1

Function

Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).

Sequence Similarities

Belongs to the peptidase T1A family.

Cellular localization

• Cytoplasm
• Nucleus
• Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9.

Alternative names

HC2, NU, PROS30, PSC2, PSMA1, Proteasome subunit alpha type-1, 30 kDa prosomal protein, Macropain subunit C2, Multicatalytic endopeptidase complex subunit C2, Proteasome component C2, Proteasome nu chain, Proteasome subunit alpha-6, PROS-30, alpha-6

Database links

swissprot:P25786 swissprot:P25788 omim:600307 swissprot:P25787 swissprot:P20618 swissprot:O14818 omim:606607 swissprot:P28066 swissprot:P18421 swissprot:P28072 swissprot:P28074 swissprot:P60900 swissprot:Q8TAA3 entrezGene:5682 entrezGene:5683 entrezGene:5684 entrezGene:5686 entrezGene:5687 entrezGene:5688 entrezGene:5689 entrezGene:5693 entrezGene:5694 entrezGene:5695 omim:602017 omim:602854 omim:604030 omim:176844 omim:176842 omim:600306