PSMD11

Function

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity.

Post-translational modifications

Phosphorylated by AMPK.

Sequence Similarities

Belongs to the proteasome subunit S9 family.

Tissue Specificity

Highly expressed in embryonic stem cells (ESCs). Expression decreases as ESCs differentiate.

Cellular localization

• Nucleus
• Cytoplasm
• Cytosol

Alternative names

26S proteasome non-ATPase regulatory subunit 11, 26S proteasome regulatory subunit RPN6, 26S proteasome regulatory subunit S9, 26S proteasome regulatory subunit p44.5, PSMD11

Database links

swissprot:O00231 entrezGene:2222 swissprot:P62195 entrezGene:5717 swissprot:Q9UNM6 swissprot:Q99460 swissprot:Q16186 swissprot:Q15008 swissprot:Q13200 swissprot:P62191 swissprot:P55036 swissprot:P51665 swissprot:P62333 swissprot:P35998 swissprot:P48556 swissprot:P43686 swissprot:P17980 swissprot:O00487 swissprot:O00232 swissprot:O43242 omim:604449 entrezGene:33622