Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.
Degraded by the proteasome upon completion of 20S proteasome maturation.
Belongs to the PSMG1 family.
In the adult, detected in brain, colon, leukocytes, breast and testis. Widely expressed in the fetus. Also expressed in a variety of proliferating cell lines.
C21LRP, DSCR2, PAC1, PSMG1, Proteasome assembly chaperone 1, PAC-1, Chromosome 21 leucine-rich protein, Down syndrome critical region protein 2, Proteasome chaperone homolog 1, C21-LRP, Pba1
Proteins
Cardiovascular
32854Da
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