PSMG1
Function
Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.
Post-translational modifications
Degraded by the proteasome upon completion of 20S proteasome maturation.
Sequence Similarities
Belongs to the PSMG1 family.
Tissue Specificity
In the adult, detected in brain, colon, leukocytes, breast and testis. Widely expressed in the fetus. Also expressed in a variety of proliferating cell lines.
Cellular localization
- Cytoplasm
- Endoplasmic reticulum
Alternative names
C21LRP, DSCR2, PAC1, PSMG1, Proteasome assembly chaperone 1, PAC-1, Chromosome 21 leucine-rich protein, Down syndrome critical region protein 2, Proteasome chaperone homolog 1, C21-LRP, Pba1