PAC-2

Function

Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.

Post-translational modifications

Degraded by the proteasome upon completion of 20S proteasome maturation.

Sequence similarities

Belongs to the PSMG2 family.

Tissue specificity

Widely expressed with highest levels in lung, brain and colon. Moderately expressed in muscle, stomach, spleen and heart. Weakly expressed in small intestine, pancreas and liver. Highly expressed in hepatocellular carcinomas with low levels in surrounding liver tissue.

Cellular localization

• Nucleus

Alternative names

• Proteasome assembly chaperone 2
• PAC-2
• Hepatocellular carcinoma-susceptibility protein 3
• Tumor necrosis factor superfamily member 5-induced protein 1
• TNFSF5IP1
• PSMG2
• PAC2
• HCCA3

Database links

• entrezGene:56984
• omim:609702
• swissprot:Q969U7

Target type

Proteins

Molecular weight

29396Da