PSPC1
Function
RNA-binding protein required for the formation of nuclear paraspeckles (PubMed:22416126). Binds to poly(A), poly(G) and poly(U) RNA homopolymers (PubMed:22416126). Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line (By similarity). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728).
Sequence Similarities
Belongs to the PSPC family.
Tissue Specificity
Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart.
Cellular localization
- Nucleus speckle
- Nucleus
- Nucleolus
- Nucleus matrix
- Cytoplasm
- In punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles (PubMed:11790299, PubMed:16148043). Colocalizes with NONO and SFPQ in paraspeckles and perinucleolar caps in an RNA-dependent manner (PubMed:11790299, PubMed:16148043). May cycle between paraspeckles and nucleolus (PubMed:11790299). In telophase, when daughter nuclei form, localizes to perinucleolar caps (PubMed:11790299).
Alternative names
PSP1, PSPC1, Paraspeckle component 1, Paraspeckle protein 1