PSPN

Function

Growth factor that exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons (PubMed:11116144, PubMed:9491986). Acts by binding to its coreceptor, GFRA4, leading to autophosphorylation and activation of the RET receptor (PubMed:11116144).

Sequence similarities

Belongs to the TGF-beta family. GDNF subfamily.

Cellular localization

• Secreted

Alternative names

• Persephin
• PSP
• PSPN

Database links

• entrezGene:5623
• omim:602921
• swissprot:O60542

Target type

Proteins

Primary research area

Oncology

Molecular weight

16600Da