PTCHD4
Function
Could act as a repressor of canonical hedgehog signaling by antagonizing the effects of SMO, as suggested by down-regulation of hedgehog target genes, including GLI1, PTCH1, and PTCH2 in PTCHD4-expressing cells.
Sequence Similarities
Belongs to the patched family.
Cellular localization
- Membrane
- Multi-pass membrane protein
Alternative names
C6orf138, PTCH53, PTCHD4, Patched domain-containing protein 4, p53-regulated patched protein