PTGER1
Function
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues.
Post-translational modifications
Phosphorylated.
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Tissue Specificity
Abundant in kidney. Lower level expression in lung, skeletal muscle and spleen, lowest expression in testis and not detected in liver brain and heart.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
Prostaglandin E2 receptor EP1 subtype, PGE receptor EP1 subtype, PGE2 receptor EP1 subtype, Prostanoid EP1 receptor, PTGER1