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PTGES3

Domain

The PXLE motif mediates interaction with EGLN1/PHD2.

Function

Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448).

Pathway

Lipid metabolism; prostaglandin biosynthesis.

Sequence similarities

Belongs to the p23/wos2 family.

Cellular localization

  • Cytoplasm

Alternative names

  • Prostaglandin E synthase 3
  • Cytosolic prostaglandin E2 synthase
  • Hsp90 co-chaperone
  • Progesterone receptor complex p23
  • Telomerase-binding protein p23
  • cPGES
  • TEBP
  • PTGES3
  • P23

Target type

Proteins

Molecular weight

18697Da