PTGES3

Domain

The PXLE motif mediates interaction with EGLN1/PHD2.

Function

Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448).

Pathway

Lipid metabolism; prostaglandin biosynthesis.

Sequence similarities

Belongs to the p23/wos2 family.

Cellular localization

• Cytoplasm

Alternative names

• Prostaglandin E synthase 3
• Cytosolic prostaglandin E2 synthase
• Hsp90 co-chaperone
• Progesterone receptor complex p23
• Telomerase-binding protein p23
• cPGES
• TEBP
• PTGES3
• P23

Database links

• entrezGene:10728
• omim:607061
• swissprot:Q15185

Target type

Proteins

Molecular weight

18697Da