PTGIS
Function
Catalyzes the biosynthesis and metabolism of eicosanoids. Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2), a potent mediator of vasodilation and inhibitor of platelet aggregation (PubMed:12372404, PubMed:15115769, PubMed:18032380, PubMed:25623425). Additionally, displays dehydratase activity, toward hydroperoxyeicosatetraenoates (HPETEs), especially toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) (PubMed:17459323).
Involvement in disease
Essential hypertension
EHT
A condition in which blood pressure is consistently higher than normal with no identifiable cause.
None
The disease may be caused by variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the cytochrome P450 family.
Tissue Specificity
Widely expressed; particularly abundant in ovary, heart, skeletal muscle, lung and prostate.
Cellular localization
- Endoplasmic reticulum membrane
- Single-pass membrane protein
Alternative names
CYP8, CYP8A1, PTGIS, Prostacyclin synthase, Hydroperoxy icosatetraenoate dehydratase, Prostaglandin I2 synthase