PTGR2

Function

Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2 (PubMed:19000823). Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation (By similarity).

Sequence Similarities

Belongs to the NADP-dependent oxidoreductase L4BD family.

Tissue Specificity

Widely expressed.

Cellular localization

• Cytoplasm

Alternative names

ZADH1, PTGR2, Prostaglandin reductase 2, PRG-2, 15-oxoprostaglandin 13-reductase, Zinc-binding alcohol dehydrogenase domain-containing protein 1

Database links

swissprot:Q8N8N7 genbank:NP_001139626.1 omim:608642 entrezGene:145482