PTGR2

Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2 (PubMed:19000823). Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation (By similarity).

Belongs to the NADP-dependent oxidoreductase L4BD family.

Widely expressed.

• Cytoplasm

ZADH1, PTGR2, Prostaglandin reductase 2, PRG-2, 15-oxoprostaglandin 13-reductase, Zinc-binding alcohol dehydrogenase domain-containing protein 1

• entrezGene:145482
• genbank:NP_001139626.1
• omim:608642
• swissprot:Q8N8N7

Proteins

38499Da