PTGR3
Function
Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficiency towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation.
Sequence Similarities
Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
Cellular localization
- Peroxisome
Alternative names
ZADH2, PTGR3, Prostaglandin reductase 3, PRG-3, Zinc-binding alcohol dehydrogenase domain-containing protein 2