PTP4A1
Developmental stage
Expressed in fetal liver.
Function
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis.
Post-translational modifications
Farnesylated. Farnesylation is required for membrane targeting. Unfarnesylated forms are shifted into the nucleus.
Sequence Similarities
Belongs to the protein-tyrosine phosphatase family.
Tissue Specificity
Expressed in bone marrow, lymph nodes, T lymphocytes, spleen, thymus and tonsil. Overexpressed in tumor cell lines.
Cellular localization
- Cell membrane
- Lipid-anchor
- Early endosome
- Endoplasmic reticulum
- Cytoplasm
- Cytoplasm
- Cytoskeleton
- Spindle
- Nucleus
- And mitotic spindle.
Alternative names
PRL1, PTPCAAX1, PTP4A1, Protein tyrosine phosphatase type IVA 1, PTP(CAAXI), Protein-tyrosine phosphatase 4a1, Protein-tyrosine phosphatase of regenerating liver 1, PRL-1