PTP4A2
Function
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB.
Post-translational modifications
Farnesylated. Farnesylation is required for membrane targeting and for interaction with RABGGTB. Unfarnesylated forms are redirected to the nucleus and cytosol.
Sequence Similarities
Belongs to the protein-tyrosine phosphatase family.
Tissue Specificity
Ubiquitously expressed, with highest levels in skeletal muscle, heart and thymus. Overexpressed in prostate tumor tissue.
Cellular localization
- Cell membrane
- Early endosome
- Cytoplasm
Alternative names
PRL2, PTPCAAX2, BM-008, PTP4A2, Protein tyrosine phosphatase type IVA 2, HU-PP-1, OV-1, PTP(CAAXII), Protein-tyrosine phosphatase 4a2, Protein-tyrosine phosphatase of regenerating liver 2, PRL-2