PTP4A3
Function
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.
Post-translational modifications
Farnesylated. Farnesylation is required for membrane targeting (By similarity).
Sequence Similarities
Belongs to the protein-tyrosine phosphatase family.
Tissue Specificity
Mainly expressed in cardiomyocytes and skeletal muscle; also found in pancreas. Consistently overexpressed in colon cancer metastasis.
Cellular localization
- Cell membrane
- Early endosome
Alternative names
PRL3, PTP4A3, Protein tyrosine phosphatase type IVA 3, PRL-R, Protein-tyrosine phosphatase 4a3, Protein-tyrosine phosphatase of regenerating liver 3, PRL-3