PTPN12
Function
Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172).
Post-translational modifications
Phosphorylated by STK24/MST3 and this results in inhibition of its activity.
Sequence Similarities
Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.
Cellular localization
- Cytoplasm
- Cell junction
- Focal adhesion
- Cell projection
- Podosome
- Partial translocation to focal adhesion sites may be mediated by interaction with SORBS2.
Alternative names
Tyrosine-protein phosphatase non-receptor type 12, PTP-PEST, Protein-tyrosine phosphatase G1, PTPG1, PTPN12