Ptprc

Developmental stage

Expression is restricted to the hematopoietic compartment of development.

Domain

The first PTPase domain interacts with SKAP1.

Function

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity). Dephosphorylates LYN, and thereby modulates LYN activity.

Post-translational modifications

Heavily N- and O-glycosylated.

Sequence Similarities

Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.

Cellular localization

• Cell membrane
• Single-pass type I membrane protein
• Membrane raft
• Synapse
• Colocalized with DPP4 in membrane rafts.

Alternative names

CD45, Ly-5, Ptprc, Receptor-type tyrosine-protein phosphatase C, Leukocyte common antigen, Lymphocyte antigen 5, T200, L-CA

Database links

swissprot:P06800 entrezGene:19264

Other research areas

• Immuno-oncology