PTPRK
Function
Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa.
Post-translational modifications
This protein undergoes proteolytic processing.
Sequence Similarities
Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
Tissue Specificity
High levels in lung, brain and colon; less in liver, pancreas, stomach, kidney, placenta and mammary carcinoma.
Cellular localization
- Cell junction
- Adherens junction
- Cell membrane
- Single-pass type I membrane protein
Alternative names
PTPK, PTPRK, Receptor-type tyrosine-protein phosphatase kappa, Protein-tyrosine phosphatase kappa, R-PTP-kappa