PTPRM
Function
Receptor protein-tyrosine phosphatase that mediates homotypic cell-cell interactions and plays a role in adipogenic differentiation via modulation of p120 catenin/CTNND1 phosphorylation (PubMed:10753936, PubMed:17761881). Promotes CTNND1 dephosphorylation and prevents its cytoplasmic localization where it inhibits SLC2A4 membrane trafficking. In turn, SLC2A4 is directed to the plasma membrane and performs its glucose transporter function (PubMed:21998202).
Sequence Similarities
Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
Cellular localization
- Cell membrane
- Single-pass type I membrane protein
- Localizes in regions of cell-cell contact.
Alternative names
PTPRL1, PTPRM, Receptor-type tyrosine-protein phosphatase mu, Protein-tyrosine phosphatase mu, R-PTP-mu