PTPRZ1
Function
Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades (By similarity).
Sequence Similarities
Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.
Tissue Specificity
Specifically expressed in the central nervous system, where it is localized in the Purkinje cell layer of the cerebellum, the dentate gyrus, and the subependymal layer of the anterior horn of the lateral ventricle. Developmentally regulated in the brain.
Cellular localization
- Isoform 1
- Cell membrane
- Single-pass type I membrane protein
- Secreted
- A secreted form is apparently generated by shedding of the extracellular domain.
- Isoform 2
- Secreted
Alternative names
HTPZP2, PTPRZ, PTPRZ2, PTPZ, PTPRZ1, Receptor-type tyrosine-protein phosphatase zeta, R-PTP-zeta, Protein-tyrosine phosphatase receptor type Z polypeptide 1, Protein-tyrosine phosphatase receptor type Z polypeptide 2, R-PTP-zeta-2