PUM3

Domain

The HA-8 region can be cleaved and exposed at the cell surface where it plays a role as a minor histocompatibility HLA-A*0201-restricted antigen.

A 90 degree bend between Pumilio repeats 3 and 4 gives rise to a L-shaped protein.

Function

Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress (PubMed:21266351). Binds to double-stranded RNA or DNA without sequence specificity (PubMed:25512524). Involved in development of the eye and of primordial germ cells (By similarity).

Tissue Specificity

Widely expressed.

Cellular localization

• Nucleus
• Nucleolus
• Nucleus
• Nucleoplasm
• Chromosome
• Localizes predominantly in the nucleolus with minor punctate signals in the nucleoplasm.

Alternative names

cPERP-C, KIAA0020, PUF-A, XTP5, PUM3, Pumilio homolog 3, HBV X-transactivated gene 5 protein, HBV XAg-transactivated protein 5, Minor histocompatibility antigen HA-8, HLA-HA8

Database links

swissprot:Q15397 genbank:NP_055693.4 entrezGene:9933 omim:609960