PWP1
Function
Chromatin-associated factor that regulates transcription (PubMed:29065309). Regulates Pol I-mediated rRNA biogenesis and, probably, Pol III-mediated transcription (PubMed:29065309). Regulates the epigenetic status of rDNA (PubMed:29065309).
Sequence Similarities
Belongs to the WD repeat PWP1 family.
Tissue Specificity
High levels seen in the placenta, skeletal muscle, kidney and pancreas while lower levels were seen in the heart, brain and lung.
Cellular localization
- Nucleus
- Nucleus
- Nucleolus
- Chromosome
- Associates with chromatin regions of rDNA.
Alternative names
Periodic tryptophan protein 1 homolog, Keratinocyte protein IEF SSP 9502, PWP1